Residents of East Harlem in Uptown Manhattan reported hearing an explosion shortly after 9:30 a.m. Wednesday morning, and a fire quickly engulfed a residence at 116th Street and Park Avenue.
The FDNY confirmed the three-alarm fire and emergency units responded quickly to the scene. NBC News is reporting at least four people have been transported to area hospitals.
Witnesses at the scene have shared video on Instagram of first responders mobilizing at the scene, as smoke billows up from the building.
Major fires being extinguished at the scene, crews and teams everywhere working to stop it. pic.twitter.com/0sP9iaDd6W
— Adnan Islam (@orangeadnan) March 12, 2014


Mashable will continue updating this story.
UPDATE: March 12, 10:35 a.m. ET: At least 11 people are now reported to be injured.
UPDATE: March 12, 10:25 a.m ET: Mashable's Lance Ulanoff compares two photos — one pre-collapse, and one-post — which show that the two buildings on longer there.
You can see the 2 buildings that were obliterated in #Harlem in this before/after image. http://t.co/75uWQqFaC2 pic.twitter.com/PlYCUfCPsY
— Lance Ulanoff (@LanceUlanoff) March 12, 2014
The FDNY shared a similar photo that shows their firefighters battling the blaze.
Now: Photo of #Manhattan collapse. #FDNY has 39 units and 168 members responding. The scene is developing. pic.twitter.com/zWhTmi9Dsm
— FDNY (@FDNY) March 12, 2014
UPDATE: March 12, 10:20 a.m. ET: Pictures of the injured being treated at the scene are beginning to surface on Twitter.
Injured being treated At scene right now. pic.twitter.com/jaWHQgtHPR
— Don Champion (@DonChampionTV) March 12, 2014
UPDATE: March 12, 10:15 a.m. ET: A local business owner tells The Daily Beast that the building was recently under construction.